Jazmine DuBois is a typical naïve and innocent ten-year-old bi-racial girl, which, to her chagrin, occasionally makes her an object of ridicule for Huey and Riley. She is the most prominent child in the show other than the Freeman boys.
Though Huey takes pleasure in criticizing her both subtly and conspicuously, he has also shown a willingness to empathize with her and tends to avoid being mean just for the sake of it. Most of the time, when he berates her, it is his way of dealing with her ignorance and naïveté in what could be construed as an unnecessarily cruel way to try to enlighten her. Though such attempts usually fail, he remains patient and tolerant. For her part, Jazmine appears to be a kind and considerate friend to Huey, as when she applauds enthusiastically for Huey's unchanged "Black Jesus" play—unlike Granddad and Riley, who fall asleep. When Jazmine starts a lemonade stand in "The Block Is Hot" and later gets exploited by Ed Wuncler Sr., Huey rallies up protesters in hopes to liberate her. In the end when the stand burns down and it begins to snow, he shares his scarf with her, reaffirming his care for her. In the nation-wide pandemic during "The Fried Chicken Flu," Jazmine is the only person Huey allows into his home other than his immediate family. In the same episode, it is once again hinted that Jazmine is probably Huey's only friend, and possibly vice versa.
In the comic book Jazmine has trouble accepting the fact that she is Multiracial, wishing her hair to be straight instead of puffy and Afro-like. She was a regularly featured character in the comic strip until 2001, when the strip took a more political focus upon which she inexplicably disappeared until the later years of the strip. During that time, Jazmine was replaced by Michael Caesar as the prominent character other than Huey and Riley Freeman. She returned to the comic strip in 2004, explaining that she had been so afraid of terrorism that she hid in her room for two years.
She appears to be quite attached to her father, crying for fear that he was kidnapped by terrorists when he doesn't come back from work in "A Date with the Health Inspector." The notable exception to this is during the episode "Tom, Sarah and Usher," when she wishes that Usher was her father instead (although this sentiment quickly passes).
Jazmine seems to mistake Santa Claus for Jesus Christ. This is an example of McGruder satirizing the unseen effects that parents lying to children can have, as well as a possible reference to Linus and the Great Pumpkin of Peanuts, which McGruder admires.